Proliferative changes seen in reactive mesothelial hyperplasia of a hydrocele sac may mimic malignant mesothelioma. There is no immunohistochemical staining that reliably separates benign from malignant mesothelial proliferations. However, the combined analysis of BAP1 by immunohistochemistry and CDKN2A by FISH has been reported to yield both a high specificity and sensitivity in this differential diagnosis. In addition, the evaluation of risk factors such as asbestos exposure or prior traumata may be helpful for the correct diagnosis. Exclusion of stromal invasion, which is diagnostic for malign mesothelioma, is of utmost importance. Therefore, extended histological workup is essential.
- Greimelmaier, K.
- Wohlschlager, J.
- Probst, A.
- Hager, T.
- Wardelmann, E.
- Werlein, C.
- Jonigk, D.
- Muller, K. M.
Keywords
- Benign mesothelial proliferation
- Hydrocele sac
- Malignant mesothelioma
- Mesothelial hyperplasia
- Tunica vaginalis of the testis
