Science and Research

Chronic Obstructive Pulmonary Disease and Pulmonary Vascular Disease. A Comorbidity?

Chronic obstructive pulmonary disease (COPD) is one of the most important causes of death worldwide, and in addition to its impact on the patient's health, it poses a major socioeconomic burden. Tobacco smoke, indoor cooking, and air pollution are major triggers of the disease. This article summarizes evidence for the concept that lung microvascular molecular alterations can be a driver of lung emphysema. If findings from preclinical models allow a transfer to the human situation, this concept can offer new approaches for curative treatment of lung emphysema.

  • Weissmann, N.

Keywords

  • chronic obstructive pulmonary disease
  • inducible nitric oxide synthase
  • lung regeneration
  • pulmonary hypertension
  • soluble guanylate cyclase
Publication details
DOI: 10.1513/AnnalsATS.201808-532MG
Journal: Annals of the American Thoracic Society
Pages: S278-S281 
Number: Supplement_4
Work Type: Original
Location: UGMLC
Disease Area: COPD, PH
Partner / Member: JLU
Access-Number: 30759003
See publication on PubMed

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