Science and Research

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer

Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.

  • Reinhold, L.
  • Mollering, A.
  • Wallis, S.
  • Palade, E.
  • Schafer, K.
  • Dromann, D.
  • Rupp, J.
  • Graspeuntner, S.
  • Dalhoff, K.

Keywords

  • innate immunity
  • lung tissue microbiome
  • respiratory infection
  • respiratory microbiome
Publication details
DOI: 10.3390/microorganisms8060794
Journal: Microorganisms
Number: 6
Work Type: Original
Location: Assoziierter Partner, ARCN
Disease Area: LC
Partner / Member: Ghd, UKSH (Lübeck)
Access-Number: 32466482
See publication on PubMed

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